Outcomes of Pediatric Patients with Malignancies of the Major Salivary Glands
- 29 June 2010
- journal article
- Published by Springer Science and Business Media LLC in Annals of Surgical Oncology
- Vol. 17 (12), 3301-3307
- https://doi.org/10.1245/s10434-010-1165-2
Abstract
Background To report the outcomes and early to long term treatment complications among pediatric patients with major salivary gland malignancies treated at a single institution. Materials and Method This study was a retrospective case review set at a tertiary referral cancer center. Patients less than 19 years of age with a diagnosis of a major salivary gland malignancy were identified at the M. D. Anderson tumor database between 1953 and 2006. Results A total of 61 patients were identified, with equal gender distribution. The majority of tumors arose in the parotid gland (83%), and the most common pathology was mucoepidermoid carcinoma (46%). Lymphatic metastasis was identified in 37% of patients, nearly all with mucoepidermoid carcinoma. Although 65% of patients had prior treatment elsewhere, more than 75% of patients underwent surgical resection at our institution. External beam radiation was used in 45% of patients, with an average dose of 58.6 Gray. Average patient follow-up was 153 months. The overall survival rate was 93% at 5 years, and 26% developed a recurrence. A second primary was identified in 2 patients. Permanent facial paresis was noted in 7 patients (12%) and xerostomia in 1 patient (4%). Conclusions Survival of pediatric patients with major salivary gland carcinomas is favorable. Adverse outcomes were best predicted by tumor grade, margin status, and neural involvement. Radiation therapy is beneficial for locoregional control of disease, with acceptable long-term treatment sequelae, and without a significant risk for developing second primary tumors. Survivorship issues need to be addressed in this patient population into adulthood.Keywords
This publication has 19 references indexed in Scilit:
- Long-term Follow-up Care for Pediatric Cancer SurvivorsPublished by American Academy of Pediatrics (AAP) ,2009
- Cancer Survivorship: A Pediatric PerspectiveThe Oncologist, 2008
- Hearing Loss After Radiotherapy for Pediatric Brain Tumors: Effect of Cochlear DoseInternational Journal of Radiation Oncology*Biology*Physics, 2008
- Proton versus photon radiotherapy for common pediatric brain tumors: Comparison of models of dose characteristics and their relationship to cognitive functionPediatric Blood & Cancer, 2008
- Radiation-Induced Craniofacial Bone Growth DisturbancesThe Journal of Craniofacial Surgery, 2007
- Salivary gland neoplasms in children: The experience of the Istituto Nazionale Tumori of MilanPediatric Blood & Cancer, 2006
- Epithelial salivary glands neoplasms in children and adolescents: A forty‐four‐year experienceMedical and Pediatric Oncology, 2002
- Salivary Gland Neoplasms in ChildrenJAMA Otolaryngology–Head & Neck Surgery, 1992
- Histopathologic Review of Salivary Gland Tumors in ChildhoodJAMA Otolaryngology–Head & Neck Surgery, 1988
- Treatment and Prognosis of Mucoepidermoid Carcinoma in the Pediatric Age GroupJAMA Otolaryngology–Head & Neck Surgery, 1985