Collagen‐based biomaterials for wound healing
Top Cited Papers
Open Access
- 14 March 2014
- journal article
- review article
- Published by Wiley in Peptide Science
- Vol. 101 (8), 821-833
- https://doi.org/10.1002/bip.22486
Abstract
With its wide distribution in soft and hard connective tissues, collagen is the most abundant of animal proteins. In vitro, natural collagen can be formed into highly organized, three‐dimensional scaffolds that are intrinsically biocompatible, biodegradable, nontoxic upon exogenous application, and endowed with high tensile strength. These attributes make collagen the material of choice for wound healing and tissue engineering applications. In this article, we review the structure and molecular interactions of collagen in vivo; the recent use of natural collagen in sponges, injectables, films and membranes, dressings, and skin grafts; and the on‐going development of synthetic collagen mimetic peptides as pylons to anchor cytoactive agents in wound beds. © 2014 Wiley Periodicals, Inc. Biopolymers 101: 821–833, 2014.Keywords
Funding Information
- NIH (R01 AR044276 and RC2 AR058971)
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