PEX16: a multifaceted regulator of peroxisome biogenesis
Open Access
- 1 January 2013
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Physiology
- Vol. 4, 241
- https://doi.org/10.3389/fphys.2013.00241
Abstract
Peroxisomes are formed by two distinct pathways: the growth and fission of mature peroxisomes and de novo synthesis at the endoplasmic reticulum (ER). While many of the molecular mechanisms underlying these two pathways remain to be elucidated, it is generally accepted that their relative contribution to peroxisome formation may vary depending on the species, cell type and/or physiological status of the organism. One pertinent example of the apparent differences in the regulation of peroxisome biogenesis among evolutionarily diverse species is the involvement of the peroxin PEX16. In Yarrowia lipolytica, for instance, PEX16 is an intraperoxisomal peripheral membrane protein that participates in peroxisomal fission. By contrast, Human PEX16 is an integral membrane protein that is thought to function at the ER during the early stages of de novo peroxisome formation and also recruits peroxisomal membrane proteins directly to mature peroxisomes. Similarly, PEX16 in the plant Arabidopsis thaliana is speculated to be a PMP receptor at the ER and peroxisomes, and is also required for the formation of other ER-derived organelles, such as oil and protein bodies. Here we briefly review the current knowledge of Y. lipolytica, human and A. thaliana PEX16 in the context of our overall understanding of peroxisome biogenesis and the role of the ER in this process in these three divergent species.Keywords
This publication has 51 references indexed in Scilit:
- The Role of the Endoplasmic Reticulum in Peroxisome BiogenesisCold Spring Harbor Perspectives in Biology, 2013
- A signal from inside the peroxisome initiates its division by promoting the remodeling of the peroxisomal membraneThe Journal of cell biology, 2007
- Lipids and lipid domains in the peroxisomal membrane of the yeast Yarrowia lipolyticaBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2006
- Arabidopsis thaliana—A model organism to study plant peroxisomesBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2006
- Peroxisome division in the yeast Yarrowia lipolytica is regulated by a signal from inside the peroxisomeThe Journal of cell biology, 2003
- Involvement of the Endoplasmic Reticulum in Peroxisome FormationMolecular Biology of the Cell, 2003
- The Membrane Biogenesis Peroxin Pex16pPublished by Elsevier BV ,2002
- Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting SequencesMolecular and Cellular Biology, 2001
- Enlarged Peroxisomes Are Present in Oleic Acid–grown Yarrowia lipolytica Overexpressing the PEX16 Gene Encoding an Intraperoxisomal Peripheral Membrane PeroxinThe Journal of cell biology, 1997
- A unified nomenclature for peroxisome biogenesis factors.The Journal of cell biology, 1996