Epigenetic regulation of CD133 and tumorigenicity of CD133 positive and negative endometrial cancer cells
Open Access
- 1 December 2010
- journal article
- Published by Springer Science and Business Media LLC in Reproductive Biology and Endocrinology
- Vol. 8 (1), 147
- https://doi.org/10.1186/1477-7827-8-147
Abstract
Recent data provide significant evidence to support the hypothesis that there are sub-populations of cells within solid tumors that have an increased tumor initiating potential relative to the total tumor population. CD133, a cell surface marker expressed on primitive cells of neural, hematopoietic, endothelial and epithelial lineages has been identified as a marker for tumor initiating cells in solid tumors of the brain, colon, pancreas, ovary and endometrium. Our objectives were to assess the relative level of CD133 expressing cells in primary human endometrial tumors, confirm their tumorigenic potential, and determine whether CD133 expression was epigenetically modified.Keywords
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