Investigation Into Sleep Disturbance of Patients Suffering from Cluster Headache
- 1 July 2005
- journal article
- clinical trial
- Published by SAGE Publications in Cephalalgia
- Vol. 25 (7), 488-492
- https://doi.org/10.1111/j.1468-2982.2004.00897.x
Abstract
The new discoveries relating to cluster headache (CH) encouraged the study of the relationship of the hypothalamus to respiratory physiology and its comorbidity with sleep apnoea. The question is whether the apnoeas are more frequent during REM sleep and the desaturations could be involved as triggers of the cluster attacks. Furthermore, could the connection with the hypothalamus, already proved, be responsible for an alteration in the structure of REM sleep and a chemoreceptor dysfunction. We set out to analyse when polysomnography investigation is necessary in patients with CH. We studied 37 patients suffering from episodic CH, 31 (83.8%) men and six (16.2%) women. For the control group, we selected 35 individuals, 31 (88.6%) men and four (11.4%) women. There was a greater percentage of obstructive sleep apnoea (OSA) in patients with CH (58.3%) compared with the control group (14.3%) and with the general population (2-4%). In cases of pain during sleep, the majority is deflagrated during the REM phase, following a desaturation episode. A stratified analysis of the apnoea/hypnoea index relating to body mass index (BMI) and age showed that patients with CH have 8.4 times more chance of exhibiting OSA than normal individuals ( P < 0001). This risk increases to 24.38 in patients with a BMI > 25 kg/m2and increases to 13.5 in patients > 40 years old. Surprisingly, the risk decreases sharply in patients with a BMI < 25 kg/m2and who are < 40 years old. Due to the fact that polysomnography is a complex, costly and sometimes difficult examination, we suggest, in concordance with the results, that it should be carried out routinely in patients with CH that exhibit a BMI of > 25 kg/m2and/or in patients who are > 40 years of age.Keywords
This publication has 28 references indexed in Scilit:
- Cluster HeadacheSouthern Medical Journal, 1998
- Cluster headache: imaging and other developmentsCurrent Opinion in Neurology, 1998
- Episodic Cluster Headache From a Textbook of 1745: Van Swieten's Classic DescriptionCephalalgia, 1993
- Respiratory Sinus Arrhythmia in Cluster Headache SyndromeHeadache: The Journal of Head and Face Pain, 1993
- The Role of PO2/PCO2 in Cluster Headache Pathogenesis: Perspectives of the Oxygen/Ozone TherapyCephalalgia, 1991
- The Effect of Hyperventilation in Cluster Headache PatientsHeadache: The Journal of Head and Face Pain, 1991
- Association of Sustained Oxyhemoglobin Desaturation and Onset of Cluster Headache AttacksHeadache: The Journal of Head and Face Pain, 1990
- Sleep and Headache Syndromes: A Clinical ReviewHeadache: The Journal of Head and Face Pain, 1990
- A Possible Role of the Carotid Body in the Pathogenesis of Cluster HeadacheCephalalgia, 1983
- Cefaleia em salvas: aspectos clinicos e terapeuticos em 26 casosArquivos de Neuro-Psiquiatria, 1980