UV Radiation and the Skin
Top Cited Papers
Open Access
- 7 June 2013
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 14 (6), 12222-12248
- https://doi.org/10.3390/ijms140612222
Abstract
UV radiation (UV) is classified as a “complete carcinogen” because it is both a mutagen and a non-specific damaging agent and has properties of both a tumor initiator and a tumor promoter. In environmental abundance, UV is the most important modifiable risk factor for skin cancer and many other environmentally-influenced skin disorders. However, UV also benefits human health by mediating natural synthesis of vitamin D and endorphins in the skin, therefore UV has complex and mixed effects on human health. Nonetheless, excessive exposure to UV carries profound health risks, including atrophy, pigmentary changes, wrinkling and malignancy. UV is epidemiologically and molecularly linked to the three most common types of skin cancer, basal cell carcinoma, squamous cell carcinoma and malignant melanoma, which together affect more than a million Americans annually. Genetic factors also influence risk of UV-mediated skin disease. Polymorphisms of the melanocortin 1 receptor (MC1R) gene, in particular, correlate with fairness of skin, UV sensitivity, and enhanced cancer risk. We are interested in developing UV-protective approaches based on a detailed understanding of molecular events that occur after UV exposure, focusing particularly on epidermal melanization and the role of the MC1R in genome maintenance.Keywords
This publication has 154 references indexed in Scilit:
- A Landscape of Driver Mutations in MelanomaCell, 2012
- Shining a Light on Xeroderma PigmentosumJournal of Investigative Dermatology, 2012
- Genetics of pigmentation in skin cancer — A reviewMutation research. Reviews in mutation research, 2010
- A comprehensive catalogue of somatic mutations from a human cancer genomeNature, 2009
- Semi-rigid tripeptide agonists of melanocortin receptorsBioorganic & Medicinal Chemistry Letters, 2009
- Short- and Long-Term Effects of UV Radiation on the Pigmentation of Human SkinJournal of Investigative Dermatology Symposium Proceedings, 2009
- Increasing Burden of Melanoma in the United StatesJournal of Investigative Dermatology, 2009
- Melanoma EpidemiologyHematology/Oncology Clinics of North America, 2009
- Physiological factors that regulate skin pigmentationBioFactors, 2009
- Differential expression of HPA axis homolog in the skinMolecular and Cellular Endocrinology, 2007