Human Alu element retrotransposition induced by genotoxic stress
- 26 October 2003
- journal article
- Published by Springer Science and Business Media LLC in Nature Genetics
- Vol. 35 (3), 219-220
- https://doi.org/10.1038/ng1259
Abstract
Alu elements are found exclusively in primate species and comprise over 10% of the human genome. To better define the mechanisms responsible for Alu replication, we introduced a human Alu element into mouse cells. We report that Alu retrotransposition can be induced in mouse cells by exposure to the topoisomerase II inhibitor etoposide and is mediated in trans by endogenous mouse long interspersed elements (LINEs).Keywords
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