A Highly Efficient and Photostable Photosensitizer with Near‐Infrared Aggregation‐Induced Emission for Image‐Guided Photodynamic Anticancer Therapy
Top Cited Papers
- 3 July 2017
- journal article
- research article
- Published by Wiley in Advanced Materials
- Vol. 29 (33)
- https://doi.org/10.1002/adma.201700548
Abstract
Photodynamic therapy (PDT), which relies on photosensitizers (PS) and light to generate reactive oxygen species to kill cancer cells or bacteria, has attracted much attention in recent years. PSs with both bright emission and efficient singlet oxygen generation have also been used for image‐guided PDT. However, simultaneously achieving effective 1O2 generation, long wavelength absorption, and stable near‐infrared (NIR) emission with low dark toxicity in a single PS remains challenging. In addition, it is well known that when traditional PSs are made into nanoparticles, they encounter quenched fluorescence and reduced 1O2 production. In this contribution, these challenging issues have been successfully addressed through designing the first photostable photosensitizer with aggregation‐induced NIR emission and very effective 1O2 generation in aggregate state. The yielded nanoparticles show very effective 1O2 generation, bright NIR fluorescence centered at 820 nm, excellent photostability, good biocompatibility, and negligible dark in vivo toxicity. Both in vitro and in vivo experiments prove that the nanoparticles are excellent candidates for image‐guided photodynamic anticancer therapy.Keywords
Funding Information
- National Natural Science Foundation of China (81220108015, 51622305)
- National Research Foundation Singapore (R279‐000‐483‐281)
- National Research Foundation Singapore (R279‐000‐444‐281)
- National University of Singapore (R279‐000‐482‐133)
This publication has 40 references indexed in Scilit:
- Oxygen-generating hybrid nanoparticles to enhance fluorescent/photoacoustic/ultrasound imaging guided tumor photodynamic therapyBiomaterials, 2017
- Ultralow-Power Near Infrared Lamp Light Operable Targeted Organic Nanoparticle Photodynamic TherapyJournal of the American Chemical Society, 2016
- Overcoming the Achilles' heel of photodynamic therapyChemical Society Reviews, 2016
- A Red Light Activatable Multifunctional Prodrug for Image‐Guided Photodynamic Therapy and Cascaded ChemotherapyAdvanced Functional Materials, 2016
- The triplet excited state of Bodipy: formation, modulation and applicationChemical Society Reviews, 2015
- Small conjugate-based theranostic agents: an encouraging approach for cancer therapyChemical Society Reviews, 2015
- Nanoparticles in Photodynamic TherapyChemical Reviews, 2015
- Nano-graphene in biomedicine: theranostic applicationsChemical Society Reviews, 2012
- The role of porphyrin chemistry in tumor imaging and photodynamic therapyChemical Society Reviews, 2010
- Photosensitizers of the porphyrin and phthalocyanine series for photodynamic therapyChemical Society Reviews, 1995