Intrarenal renin-angiotensin system and counteracting protective mechanisms in angiotensin II-dependent hypertension
- 1 March 2007
- journal article
- review article
- Published by Akademiai Kiado Zrt. in Acta Physiologica Hungarica
- Vol. 94 (1), 31-48
- https://doi.org/10.1556/aphysiol.94.2007.1-2.5
Abstract
It is now well accepted that alterations in kidney function, due either to primary renal disease or to inappropriate hormonal influences on the kidney, are a cardinal characteristic in all forms of hypertension, and lead to a reduced ability of the kidneys to excrete sodium and the consequent development of elevated arterial pressures (1, 2). However, it is also apparent that many extrarenal factors are important contributors to altered kidney function and hypertension. Central to many hypertensinogenic processes is the inappropriate activation of the renin-angiotensin system (RAS) and its downstream consequences by various pathophysiologic mechanisms (3, 4). There may also be derangements in arachidonic acid metabolites, endothelium derived factors such as nitric oxide and carbon monoxide, and various paracrine and neural systems that normally interact with or provide a counteracting balance to the actions of the RAS. Thus, when the capacity of the kidneys to maintain sodium balance and extracellular fluid volume within appropriate ranges is compromised, increases in arterial pressure become necessary to re-establish normal balance (2, 5, 6)Keywords
This publication has 96 references indexed in Scilit:
- Interactive effects of superoxide anion and nitric oxide on blood pressure and renal hemodynamics in transgenic rats with inducible malignant hypertensionAmerican Journal of Physiology-Renal Physiology, 2005
- TP receptors regulate renal hemodynamics during angiotensin II slow pressor responseAmerican Journal of Physiology-Renal Physiology, 2004
- Oxidative Stress in Dahl Salt-Sensitive HypertensionHypertension, 2003
- Angiotensin II–Induced Hypertension in Bradykinin B 2 Receptor Knockout MiceHypertension, 2001
- Angiotensin II Activates the Proinflammatory Transcription Factor Nuclear Factor-κB in Human MonocytesBiochemical and Biophysical Research Communications, 1999
- Normalization of Blood Pressure and Renal Vascular Resistance in SHR With a Membrane-Permeable Superoxide Dismutase MimeticHypertension, 1998
- The Role of Eicosanoids in Angiotensin-Dependent HypertensionHypertension, 1998
- Hypotension in Transgenic Mice Overexpressing Human Bradykinin B 2 ReceptorHypertension, 1997
- Renal nitric oxide and angiotensin II interaction in renovascular hypertension.Hypertension, 1993
- Molecular basis of human hypertension: Role of angiotensinogenCell, 1992