Stress-Induced Allodynia – Evidence of Increased Pain Sensitivity in Healthy Humans and Patients with Chronic Pain after Experimentally Induced Psychosocial Stress
Open Access
- 7 August 2013
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 8 (8), e69460
- https://doi.org/10.1371/journal.pone.0069460
Abstract
Experimental stress has been shown to have analgesic as well as allodynic effect in animals. Despite the obvious negative influence of stress in clinical pain conditions, stress-induced alteration of pain sensitivity has not been tested in humans so far. Therefore, we tested changes of pain sensitivity using an experimental stressor in ten female healthy subjects and 13 female patients with fibromyalgia. Multiple sensory aspects of pain were evaluated in all participants with the help of the quantitative sensory testing protocol before (60 min) and after (10 and 90 min) inducing psychological stress with a standardized psychosocial stress test (“Trier Social Stress Test”). Both healthy subjects and patients with fibromyalgia showed stress-induced enhancement of pain sensitivity in response to thermal stimuli. However, only patients showed increased sensitivity in response to pressure pain. Our results provide evidence for stress-induced allodynia/hyperalgesia in humans for the first time and suggest differential underlying mechanisms determining response to stressors in healthy subjects and patients suffering from chronic pain. Possible mechanisms of the interplay of stress and mediating factors (e.g. cytokines, cortisol) on pain sensitivity are mentioned. Future studies should help understand better how stress impacts on chronic pain conditions.This publication has 65 references indexed in Scilit:
- Predictive relationships between chronic pain and negative emotions: a 4-month daily process study using Therapeutic Interactive Voice Response (TIVR)Comprehensive Psychiatry, 2011
- Enhanced cytokine-induced mechanical hyperalgesia in skeletal muscle produced by a novel mechanism in rats exposed to unpredictable sound stressEuropean journal of pain, 2011
- Cellular and Molecular Mechanisms of PainCell, 2009
- Peripheral mechanisms of pain and analgesiaBrain Research Reviews, 2009
- Descending control of nociception: Specificity, recruitment and plasticityBrain Research Reviews, 2009
- Synergistic effects of psychological and immune stressors on inflammatory cytokine and sickness responses in humansBrain, Behavior, and Immunity, 2009
- Muscle Inflammation Induces a Protein Kinase Cε–Dependent Chronic-Latent Muscle PainThe Journal of Pain, 2008
- Similarities in stress physiology among patients with chronic pain and headache disorders: evidence for a common pathophysiological mechanism?The Journal of Headache and Pain, 2008
- Quantitative sensory testing: a comprehensive protocol for clinical trialsEuropean journal of pain, 2006
- Subgrouping of fibromyalgia patients on the basis of pressure‐pain thresholds and psychological factorsArthritis & Rheumatism, 2003