Disease Diagnosis by Recombinant DNA Methods
- 5 June 1987
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 236 (4806), 1223-1229
- https://doi.org/10.1126/science.3296189
Abstract
Recombinant DNA procedures have now been applied to the problem of the identification of molecular defects in man that account for heritable diseases, somatic mutations associated with neoplasia, and acquired infectious disease. Thus recombinant DNA technology has rapidly expanded our ability to diagnose disease. Substantial advances in the simplification of procedures for diagnostic purposes have been made, and the informed physician has gained in diagnostic accuracy as a consequence of these developments. The wide application of recombinant DNA diagnostics will depend on simplicity, speed of results, and cost containment.Keywords
This publication has 63 references indexed in Scilit:
- Prediction of Familial Predisposition to RetinoblastomaNew England Journal of Medicine, 1986
- Association of Multiple Copies of the N-mycOncogene with Rapid Progression of NeuroblastomasNew England Journal of Medicine, 1985
- Genetic Screening for Hemophilia A (Classic Hemophilia) with a Polymorphic DNA ProbeNew England Journal of Medicine, 1985
- Nucleic acid probes in diagnosis of viral diseases of manArchiv für die gesamte Virusforschung, 1985
- Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresisCell, 1984
- Prenatal Diagnosis of α1-Antitrypsin Deficiency by Direct Analysis of the Mutation Site in the GeneNew England Journal of Medicine, 1984
- A Sensitive New Prenatal Test for Sickle-Cell AnemiaNew England Journal of Medicine, 1982
- Molecular Epidemiology of Antibiotic Resistance in Salmonella from Animals and Human Beings in the United StatesNew England Journal of Medicine, 1982
- Phenylketonuria: Epitome of Human Biochemical GeneticsNew England Journal of Medicine, 1980
- Neonatal circumcision and penile dorsal nerve block—a painless procedureThe Journal of Pediatrics, 1978