Detection of Relevant Coronary Artery Disease Using Dual-Source Computed Tomography in a High Probability Patient Series Comparison With Invasive Angiography
- 1 January 2009
- journal article
- research article
- Published by Japanese Circulation Society in Circulation Journal
- Vol. 73 (2), 316-322
- https://doi.org/10.1253/circj.cj-08-0534
Abstract
Background Computed tomography (CT) enables detection of coronary artery stenoses, but its use is limited by deficient evaluation at elevated heart rates. The accuracy of dual-source CT (DSCT) for the detection of coronary artery disease (CAD) was assessed in 76 patients at high probability of CAD without heart rate control and compared with quantitative coronary angiography (QCA). Methods and Results The 76 patients (47 males, mean age 65.5±10 years) underwent DSCT without preceding heart rate control. Data sets were evaluated by 2 observers in consensus with respect to stenoses >50% decreased diameter. QCA served as the standard of reference. Mean heart rate during scanning was 68±9 beats per min, and the average Agatston score was 337±560. Of 1,160 coronary artery segments, all but 3 were visualized artefact-free; 58 coronary stenoses were correctly detected by CT angiography. In the segment-based analysis, sensitivity was 98.3%, specificity 99.2% and accuracy 99%; patient based analysis revealed a sensitivity of 100%, specificity of 83.3% and overall accuracy of 92.1%. Conclusions Even at elevated heart rates, DSCT can reliably detect coronary artery stenoses and the results correlate well with those for invasive coronary angiography. (Circ J 2009; 73: 316 - 322)Keywords
This publication has 41 references indexed in Scilit:
- Quantifizierung von Stenosen der KoronararterienDer Radiologe, 2007
- Accuracy of dual-source CT coronary angiography: first experience in a high pre-test probability population without heart rate controlEuropean Radiology, 2006
- Accuracy of 64-MDCT in the Diagnosis of Ischemic Heart DiseaseAmerican Journal of Roentgenology, 2006
- Dual-source CT cardiac imaging: initial experienceEuropean Radiology, 2006
- Contrast-enhanced coronary artery visualization by dual-source computed tomography—Initial experienceEuropean Journal of Radiology, 2006
- First performance evaluation of a dual-source CT (DSCT) systemEuropean Radiology, 2005
- Usefulness of Multidetector Row Spiral Computed Tomography With 64- × 0.6-mm Collimation and 330-ms Rotation for the Noninvasive Detection of Significant Coronary Artery StenosesThe American Journal of Cardiology, 2005
- Diagnostic Accuracy of Noninvasive Coronary Angiography Using 64-Slice Spiral Computed TomographyJournal of the American College of Cardiology, 2005
- Multislice spiral computed tomography coronary angiography in patients with stable angina pectorisJournal of the American College of Cardiology, 2004
- Detection of Coronary Artery Stenoses With Thin-Slice Multi-Detector Row Spiral Computed Tomography and Multiplanar ReconstructionCirculation, 2003