Cerebral microbleeds in idiopathic normal pressure hydrocephalus
Open Access
- 1 December 2015
- journal article
- research article
- Published by Springer Science and Business Media LLC in Fluids and Barriers of the CNS
- Vol. 13 (1), 4
- https://doi.org/10.1186/s12987-016-0028-z
Abstract
A vascular disease could be involved in pathophysiology of normal pressure hydrocephalus (INPH). If so, there should be an association between INPH and cerebral microbleeds (CMB). This study aims to analyze if CMB are associated with INPH. In this case-control study we included 14 patients with INPH (mean age 76 years, 60 % female) and 41 healthy controls (HeCo; mean age 71 years, 60 % female). All were investigated with magnetic resonance imaging (MRI) using a T2*-sequence. The MRI exams were reviewed by two neuroradiologists for the presence of CMBs; the prevalence of findings of two or more CMBs was compared between INPH group and control group. After investigation, INPH patients underwent shunt surgery. Two or more CMB were detected more frequently in the INPH group compared to HeCo (n = 6, 43 % vs. n = 4, 10 %; p = 0.01). Among the participants where MRI revealed CMB, the number of CMB was higher among the INPH patients than the HeCo (median 8; IQR 2-34 vs. median 1; IQR 1–2; p = 0.005). This study supports a vascular component to the pathophysiology of INPH.Keywords
Funding Information
- Vetenskapsrådet (621-2011-5216)
This publication has 17 references indexed in Scilit:
- Influence of comorbidities in idiopathic normal pressure hydrocephalus — research and clinical care. A report of the ISHCSF task force on comorbidities in INPHFluids and Barriers of the CNS, 2013
- Cerebral microbleeds are associated with worse cognitive functionNeurology, 2012
- Periventricular and deep white matter leukoaraiosis have a closer association with cerebral microbleeds than ageEuropean Journal of Neurology, 2011
- Intracerebral Hemorrhage Secondary to Ventriculoperitoneal Shunt Insertion -Four Case Reports-Neurologia medico-chirurgica, 2010
- The Microbleed Anatomical Rating Scale (MARS)Neurology, 2009
- Cerebral microbleeds: a guide to detection and interpretationThe Lancet Neurology, 2009
- Prevalence and risk factors of cerebral microbleedsNeurology, 2008
- Cerebral microbleeds in the population based AGES-Reykjavik study: prevalence and locationJournal of Neurology, Neurosurgery & Psychiatry, 2008
- Idiopathic normal pressure hydrocephalusPractical Neurology, 2006
- Vascular Risk Factors and Arteriosclerotic Disease in Idiopathic Normal-Pressure Hydrocephalus of the ElderlyStroke, 1996