Smad2 and Smad4 gene mutations in hepatocellular carcinoma
- 26 August 1999
- journal article
- research article
- Published by Springer Science and Business Media LLC in Oncogene
- Vol. 18 (34), 4879-4883
- https://doi.org/10.1038/sj.onc.1202866
Abstract
TGF-β is a negative regulator of liver growth. Smad family of genes, as mediators of TGF-β pathway, are candidate tumor suppressor genes in hepatocellular carcinoma (HCC). We studied 35 HCC and non-tumour liver tissues for possible mutations in Smad2 and Smad4 genes. Three tumours displayed somatic mutations; two in Smad4 (Asp332Gly and Cys401Arg) and one in Smad2 (Gln407Arg) genes. All three mutations were A:T → G:C transitions suspected to result from oxidative stress as observed in mitochondrial DNA. These observation demonstrate that TGF-β pathway is altered in hepatocellular carcinoma.Keywords
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