Uterine leiomyoma in the Eker rat: A unique model for important diseases of women
- 14 October 2003
- journal article
- review article
- Published by Wiley in Genes, Chromosomes and Cancer
- Vol. 38 (4), 349-356
- https://doi.org/10.1002/gcc.10281
Abstract
Eker rats carry a defect in the Tsc‐2 tumor suppressor gene and female Eker rats develop uterine leiomyoma with a high frequency. The presentation, response to hormones and molecular alterations in these mesenchymal smooth muscle tumors, closely resembles their cognate human disease. Female rats and tumor‐derived cell lines from Eker rat leiomyomas (ELT lines) have been developed as an in vivo/in vitro model system for preclinical studies to identify novel therapeutic agents for this disease and for studying disease pathogenesis. In addition to serving as a model for uterine leiomyoma, Eker rats have proven valuable for studying lymphangioleiomyomatosis, a related proliferative smooth muscle disease of women.Keywords
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