Structural and Functional Evolution of Vertebrate Neuroendocrine Stress Systems
- 27 April 2009
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1163 (1), 1-16
- https://doi.org/10.1111/j.1749-6632.2009.04433.x
Abstract
The vertebrate hypothalamus-pituitary-adrenal (HPA; or interrenal) axis plays pivotal roles in animal development and in physiological and behavioral adaptation to environmental change. The HPA, or stress axis, is organized in a hierarchical manner, with feedback operating at several points along the axis. Recent findings suggest that the proteins, gene structures, and signaling pathways of the HPA axis were present in the earliest vertebrates and have been maintained by natural selection owing to their critical adaptive roles. In all vertebrates studied, the HPA axis is activated in response to stressors and is controlled centrally by peptides of the corticotropin-releasing factor (CRF) family of which four paralogous members have been identified. Signaling by CRF-like peptides is mediated by at least two distinct G protein-coupled receptors and modulated by a secreted binding protein. These neuropeptides function as hypophysiotropins and as neurotransmitters/neuromodulators, influencing stress-related behaviors, such as anxiety and fear. In addition to modulating HPA activity and behavioral stress responses, CRF-like peptides are implicated in timing key life history transitions, such as metamorphosis in amphibians and birth in mammals. CRF-like peptides and signaling components are also expressed outside of the central nervous system where they have diverse physiological functions. Glucocorticoids are the downstream effectors of the HPA axis, playing essential roles in development, energy balance and behavior, and feedback actions on the activity of the HPA axis.Keywords
This publication has 102 references indexed in Scilit:
- Sequences, expression patterns and regulation of the corticotropin-releasing factor system in a teleostGeneral and Comparative Endocrinology, 2008
- Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: Ancient CRF paralogsFrontiers in Neuroendocrinology, 2007
- Localization of corticotropin‐releasing factor, urotensin I, and CRF‐binding protein gene expression in the brain of the zebrafish, Danio rerioJournal of Comparative Neurology, 2007
- Hippocampal neuroplasticity induced by early-life stress: Functional and molecular aspectsFrontiers in Neuroendocrinology, 2006
- Transcriptional regulation by the phosphorylation-dependent factor CREBNature Reviews Molecular Cell Biology, 2001
- Non-genomic Mechanisms of Glucocorticoid Inhibition of Adrenocorticotropin Secretion: Possible Involvement of GTP-Binding ProteinBiochemical and Biophysical Research Communications, 1997
- Stress, Feedback and Facilitation in the Hypothalamo‐Pituitary‐Adrenal AxisJournal of Neuroendocrinology, 1992
- Structural analysis of the regulatory region of the human corticotropin releasing hormone geneFEBS Letters, 1990
- In vitro study of immunoreactive corticotropin-releasing factor release from the rat hypothalamusLife Sciences, 1985
- Seasonal and stress related changes in plasma gonadotropins, sex steroids, and corticosterone in the bullfrog, Rana catesbeianaGeneral and Comparative Endocrinology, 1983