Intrauterine nutrition: its importance during critical periods for cardiovascular and endocrine development
Open Access
- 1 February 1999
- journal article
- Published by Wiley in The Journal of Physiology
- Vol. 514 (3), 617-627
- https://doi.org/10.1111/j.1469-7793.1999.617ad.x
Abstract
Experimental investigations in animals have highlighted the role of early reduced calorie and protein nutrition on fetal cardiovascular development, and the occurrence of a transition from a low fetal arterial blood pressure in late gestation to a high arterial blood pressure postnatally. These observations may explain the correlation between health, including appropriate nutrition, in pregnant women and the outcome of their pregnancies. Emphasis has been placed on low birth weight infants who have an increased risk of developing cardiovascular diseases, including hypertension, coronary heart disease and stroke in adulthood. Vascular pathology in adults is not always associated with low birth weight and animal experiments indicate that substantial changes in cardiovascular and endocrine function can result from maternal or fetal undernutrition without impairing fetal growth. Experimental investigation on organogenesis shows the pivotal role of adequate protein availability as well as total caloric intake. Amino acid metabolism in the feto-maternal unit appears to have a key influence on the development of organs involved in chronic degenerative disease in the adult. Experimental investigation has also highlighted the role of carbohydrate metabolism and its effect on the fetus in this respect. Either restriction of protein intake or diabetes in pregnant rats has intergenerational effects at least on the endocrine pancreas and the brain. Further investigation is needed to clarify the mechanisms involved and lead to a new understanding of the importance of nutrition during pregnancy. This will provide an important approach to the primary prevention of diabetes and chronic degenerative diseases.This publication has 74 references indexed in Scilit:
- Effects of hypoxemia on 11β-hydroxysteroid dehydrogenase types 1 and 2 gene expression in preterm fetal sheepJournal of the Society for Gynecologic Investigation, 1997
- Activation of the fetal hypothalamic-pituitary-adrenal axis with prolonged and graded hypoxemiaJournal of the Society for Gynecologic Investigation, 1997
- Stimulatory effects of taurine on insulin secretion by fetal rat islets cultured in vitroJournal of Endocrinology, 1996
- Maternal influences on adult blood pressure of SHRS: A single pup cross-fostering studyPhysiology & Behavior, 1996
- Impaired activity of rat pancreatic islet mitochondrial glycerophosphate dehydrogenase in protein malnutritionEndocrinology, 1995
- Retard de croissance intra-utérin et déficit en néphronsmédecine/sciences, 1993
- Altered Electrolyte and Taurine Levels in Milk from Nursing Hypertensive Rats.Hypertension Research, 1993
- The time-course of ACTH stimulation of cortisol synthesis by the immature ovine foetal adrenal glandThe Journal of Steroid Biochemistry and Molecular Biology, 1992
- The role of diet during development on the regulation of adult cholesterol homeostasisCanadian Journal of Physiology and Pharmacology, 1985
- Generational effects of protein malnutrition in the ratDevelopmental Brain Research, 1984