Tetracyclic indole alkaloids with antinematode activity from Uncaria rhynchophylla
- 11 November 2016
- journal article
- research article
- Published by Taylor & Francis Ltd in Natural Product Research
- Vol. 31 (12), 1403-1408
- https://doi.org/10.1080/14786419.2016.1255885
Abstract
A new tetracyclic indole alkaloid, 17-O-methyl-3,4,5,6-tetradehydrogeissoschizine, together with seven known ones, were isolated from the aerial part of Uncaria rhynchophylla. Their structures were unambiguously elucidated by spectroscopic methods and comparing with the literature data. Among them, compounds 1, 3, 4 and 6–8 showed potent to moderate antinematode activities against Panagrellus redivevus at a concentration of 250 μg/mL.Keywords
Funding Information
- Natural Science Foundation of Hainan Province (20152035)
- Agro-Scientific Research in the Public Interest (201303117)
- National Nonprofit Institute Research Grant of CATAS-ITBB (ITBB2016)
- Natural Science Foundation of China (31300294)
This publication has 14 references indexed in Scilit:
- Geissoschizine methyl etherN-oxide, a new alkaloid with antiacetylcholinesterase activity fromUncaria rhynchophyllaNatural Product Research, 2014
- Alkaloids from the hook-bearing branch ofUncariarhynchophyllaand their neuroprotective effects against glutamate-induced HT22 cell deathJournal of Asian Natural Products Research, 2014
- New monoterpenoid alkaloids from the aerial parts of Uncaria hirsutaNatural Product Research, 2014
- Geissoschizine methyl ether, a corynanthean-type indole alkaloid fromUncaria rhynchophyllaas a potential acetylcholinesterase inhibitorNatural Product Research, 2012
- Enantioselective Formal Synthesis of (+)-Dihydrocorynantheine and (−)-DihydrocorynantheolThe Journal of Organic Chemistry, 2008
- Alkaloids from the Leaves of Uncaria rhynchophylla and Their Inhibitory Activity on NO Production in Lipopolysaccharide-Activated MicrogliaJournal of Natural Products, 2008
- Ethnobotany, phytochemistry and pharmacology of Uncaria (Rubiaceae)Phytochemistry, 2005
- Effect on locomotion of indole alkaloids from the hooks of Uncaria plantsPhytomedicine, 1999
- Alkaloids of Rauwolfia mombasiana Stem BarkPlanta Medica, 1979
- The partial synthesis of heteroyohimbine alkaloids; akuammigine, 3-isorauniticine and corynanthe alkaloid; corynantheidine.CHEMICAL & PHARMACEUTICAL BULLETIN, 1978