Derivation and Maintenance of Virtual Memory CD8 T Cells
- 15 March 2012
- journal article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 188 (6), 2516-2523
- https://doi.org/10.4049/jimmunol.1102213
Abstract
Memory CD8+ T cells are an important component of the adaptive immune response against many infections, and understanding how Ag-specific memory CD8+ T cells are generated and maintained is crucial for the development of vaccines. We recently reported the existence of memory-phenotype, Ag-specific CD8+ T cells in unimmunized mice (virtual memory or VM cells). However, it was not clear when and where these cells are generated during normal development, nor the factors required for their production and maintenance. This issue is especially pertinent given recent data showing that memory-like CD8 T cells can be generated in the thymus, in a bystander response to IL-4. In this study, we show that the size of the VM population is reduced in IL-4R–deficient animals. However, the VM population appears first in the periphery and not the thymus of normal animals, suggesting this role of IL-4 is manifest following thymic egress. We also show that the VM pool is durable, showing basal proliferation and long-term maintenance in normal animals, and also being retained during responses to unrelated infection.Keywords
This publication has 47 references indexed in Scilit:
- Alternative memory in the CD8 T cell lineageTrends in Immunology, 2011
- SAP Protein-Dependent Natural Killer T-like Cells Regulate the Development of CD8+ T Cells with Innate Lymphocyte CharacteristicsImmunity, 2010
- T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cellsNature Immunology, 2010
- Diversity in T Cell Memory: An Embarrassment of RichesImmunity, 2009
- KLF2 Transcription-Factor Deficiency in T Cells Results in Unrestrained Cytokine Production and Upregulation of Bystander Chemokine ReceptorsImmunity, 2009
- Surviving the crash: Transitioning from effector to memory CD8+ T cellSeminars in Immunology, 2009
- The nature of the lymphopenic environment dictates protective function of homeostatic-memory CD8 + T cellsProceedings of the National Academy of Sciences of the United States of America, 2008
- Memory Inflation during Chronic Viral Infection Is Maintained by Continuous Production of Short-Lived, Functional T CellsImmunity, 2008
- Endogenous Naive CD8+ T Cell Precursor Frequency Regulates Primary and Memory Responses to InfectionImmunity, 2008
- Naive CD4+ T Cell Frequency Varies for Different Epitopes and Predicts Repertoire Diversity and Response MagnitudeImmunity, 2007