Ectoine in the Treatment of Irritations and Inflammations of the Eye Surface
Open Access
- 9 February 2021
- journal article
- research article
- Published by Hindawi Limited in BioMed Research International
- Vol. 2021, 1-16
- https://doi.org/10.1155/2021/8885032
Abstract
The ocular surface is facing various unspecific stress factors resulting in irritation and inflammation of the epithelia, causing discomfort to the patients. Ectoine is a bacteria-derived extremolyte with the ability to protect proteins and biological membranes from damage caused by extreme environmental conditions like heat, UV-light, high osmolarity, or dryness. Evidence from preclinical and clinical studies attest its effectiveness in treating several epithelium-associated inflammatory diseases, including the eye surface. In this review, we analysed 16 recent clinical trials investigating ectoine eye drops in patients with allergic conjunctivitis or with other unspecific ocular inflammations caused by e.g. ophthalmic surgery. Findings from these studies were reviewed in context with other published work on ectoine. In summary, patients with irritations and unspecific inflammations of the ocular surface have been treated successfully with ectoine-containing eye drops. In these patients, significant improvement was observed in ocular symptoms of allergic rhinoconjunctivitis, postoperative secondary dry eye syndrome, or ocular reepithelisation after surgery. Using ectoine as an add-on therapy to antihistamines, in allergy patients accelerated symptom relief by days, and its use as an add-on to antibiotics resulted in faster wound closure. Ectoine is a natural substance with an excellent tolerability and safety profile thus representing a helpful alternative for patients with inflammatory irritation of the ocular surface, who wish to avoid local reactions and side effects associated with pharmacological therapies or wish to increase the efficacy of standard treatment regimen.Funding Information
- bitop AG
This publication has 54 references indexed in Scilit:
- Ectoine-Containing Cream in the Treatment of Mild to Moderate Atopic Dermatitis: A Randomised, Comparator-Controlled, Intra-Individual Double-Blind, Multi-Center TrialSkin Pharmacology and Physiology, 2013
- Carbon nanoparticles induce ceramide- and lipid raft-dependent signalling in lung epithelial cells: a target for a preventive strategy against environmentally-induced lung inflammationParticle and Fibre Toxicology, 2012
- Properties of compatible solutes in aqueous solutionBiophysical Chemistry, 2012
- Compatible solutes: Ectoine and hydroxyectoine improve functional nanostructures in artificial lung surfactantsBiochimica et Biophysica Acta (BBA) - Biomembranes, 2011
- Post-LASIK dry eyeExpert Review of Ophthalmology, 2011
- Ectoin®, a Novel, Non-Drug, Extremophile-Based Device, Relieves Allergic Rhinoconjunctivitis Symptoms in Patients in an Environmental Exposure Chamber ModelJournal of Allergy and Clinical Immunology, 2011
- PRISMA StatementEpidemiology, 2011
- c-Src-mediated activation of Erk1/2 is a reaction of epithelial cells to carbon nanoparticle treatment and may be a target for a molecular preventive strategyBiological Chemistry, 2010
- The effect of compatible solute ectoines on the structural organization of lipid monolayer and bilayer membranesBiophysical Chemistry, 2010
- Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*Allergy, 2008