Users' Guides to the Medical Literature
- 16 April 1997
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 277 (15), 1232-1237
- https://doi.org/10.1001/jama.1997.03540390062037
Abstract
CLINICAL SCENARIO You are a physician following a 35-year-old man who has had active Crohn disease for 8 years. The symptoms were severe enough to require resectional surgery 4 years ago, and despite treatment with sulfasalazine and metronidazole, the patient has had active disease requiring oral steroids for the last 2 years. Repeated attempts to decrease the prednisone have failed, and the patient has required doses of greater than 15 mg per day to control symptoms. You are impressed by both the methods and results of a recent article1documenting that such patients benefit from oral methotrexate and suggest to the patient that he consider this medication. When you explain some of the risks of methotrexate, particularly potential liver toxicity, the patient is hesitant. How much better, he asks, am I likely to feel while taking this medication? INTRODUCTION There are 3 reasons we offer treatment to our patients.Keywords
This publication has 19 references indexed in Scilit:
- Linking clinical variables with health-related quality of life. A conceptual model of patient outcomesPublished by American Medical Association (AMA) ,1995
- Measuring Quality of Life in AsthmaAmerican Review of Respiratory Disease, 1993
- Measuring health status: What are the necessary measurement properties?Journal of Clinical Epidemiology, 1992
- Randomized Controlled Multicentre Evaluation of an Education Programme for Insulin-treated Diabetic Patients: Effects on Metabolic Control, Quality of Life, and Costs of TherapyDiabetic Medicine, 1991
- The relationship between exercise tolerance and quality of life in angina pectorisClinical Cardiology, 1991
- The Medical Outcomes Study. An application of methods for monitoring the results of medical carePublished by American Medical Association (AMA) ,1989
- Relative efficacy of vasodilator therapy in chronic congestive heart failure. Implications of randomized trialsJAMA, 1988
- A measure of quality of life for clinical trials in chronic lung disease.Thorax, 1987
- A methodological framework for assessing health indicesJournal of Chronic Diseases, 1985
- The Sickness Impact Profile: Development and Final Revision of a Health Status MeasureMedical Care, 1981