Gerfelin, a Novel Inhibitor of Geranylgeranyl Diphosphate Synthase from Beauveria felina QN22047: I. Taxonomy, Fermentation, Isolation, and Biological Activities

Abstract

This is the first study to report the isolation of an inhibitor of geranylgeranyl diphosphate (GGDP). Posttranslational modifications involving the transfer of an isoprenoid moiety from GGDP are essential for the function of Rho and Rac family proteins. They have an important role in cytoskeletal organization, cancer metastasis, and the proliferation of cancer cells. Gerfelin isolated from a fungus, B. felina, inhibited synthesis...