β-Cell Function in Obese-Hyperglycemic Mice [ob/ob Mice]
- 15 January 2010
- book chapter
- review article
- Published by Springer Science and Business Media LLC in Advances in experimental medicine and biology
- Vol. 654, 463-477
- https://doi.org/10.1007/978-90-481-3271-3_20
Abstract
This review summarizes key aspects of what has been learned about the physiology of pancreatic islets and leptin deficiency from studies in obese ob/ob mice. ob/ob Mice lack functional leptin. They are grossly overweight and hyperphagic particularly at young ages and develop severe insulin resistance with hyperglycemia and hyperinsulinemia. ob/ob Mice have large pancreatic islets. The β-cells respond adequately to most stimuli, and ob/ob mice have been used as a rich source of pancreatic islets with high insulin release capacity. ob/ob Mice can perhaps be described as a model for the prediabetic state. The large capacity for islet growth and insulin release makes ob/ob mice a good model for studies on how β-cells can cope with prolonged functional stress.Keywords
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