Factors Associated with Marburg Hemorrhagic Fever: Analysis of Patient Data from Uige, Angola
Open Access
- 15 June 2010
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 201 (12), 1909-1918
- https://doi.org/10.1086/652748
Abstract
Background. Reliable on-site polymerase chain reaction (PCR) testing for Marburg hemorrhagic fever (MHF) is not always available. Therefore, clinicians triage patients on the basis of presenting symptoms and contact history. Using patient data collected in Uige, Angola, in 2005, we assessed the sensitivity and specificity of these factors to evaluate the validity of World Health Organization (WHO)-recommended case definitions for MHF. Methods. Multivariable logistic regression was used to identify independent predictors of PCR confirmation of MHF. A data-derived algorithm was developed to obtain new MHF case definitions with improved sensitivity and specificity. Results. A MHF case definition comprising (1) an epidemiological link or (2) the combination of myalgia or arthralgia and any hemorrhage could potentially serve as an alternative to current case definitions. Our dataderived case definitions maintained the sensitivity and improved the specificity of current WHO-recommended case definitions. Conclusions. Continued efforts to improve clinical documentation during filovirus outbreaks would aid in the refinement of case definitions and facilitate outbreak control.Keywords
This publication has 24 references indexed in Scilit:
- Studies of Reservoir Hosts for Marburg VirusEmerging Infectious Diseases, 2007
- The Médecins Sans Frontières Intervention in the Marburg Hemorrhagic Fever Epidemic, Uige, Angola, 2005. I. Lessons Learned in the HospitalThe Journal of Infectious Diseases, 2007
- Marburg Hemorrhagic Fever in Durba and Watsa, Democratic Republic of the Congo: Clinical Documentation, Features of Illness, and TreatmentThe Journal of Infectious Diseases, 2007
- High‐Throughput Molecular Detection of Hemorrhagic Fever Virus Threats with Applications for Outbreak SettingsThe Journal of Infectious Diseases, 2007
- The Médecins Sans Frontières Intervention in the Marburg Hemorrhagic Fever Epidemic, Uige, Angola, 2005. II. Lessons Learned in the CommunityThe Journal of Infectious Diseases, 2007
- Marburg Virus Infection Detected in a Common African BatPLOS ONE, 2007
- Marburg Hemorrhagic Fever Associated with Multiple Genetic Lineages of VirusNew England Journal of Medicine, 2006
- Marburgvirus Genomics and Association with a Large Hemorrhagic Fever Outbreak in AngolaJournal of Virology, 2006
- Marburg and Ebola — Arming Ourselves against the Deadly FilovirusesNew England Journal of Medicine, 2005
- Diagnostic accuracy of physician review, expert algorithms and data-derived algorithms in adult verbal autopsies.International Journal of Epidemiology, 1999