Current challenges and future opportunities of phage therapy
- 31 October 2020
- journal article
- review article
- Published by Oxford University Press (OUP) in FEMS Microbiology Reviews
- Vol. 44 (6), 684-700
- https://doi.org/10.1093/femsre/fuaa017
Abstract
Antibiotic resistance is a major public health challenge worldwide, whose implications for global health might be devastating if novel antibacterial strategies are not quickly developed. As natural predators of bacteria, (bacterio)phages may play an essential role in escaping such a dreadful future. The rising problem of antibiotic resistance has revived the interest in phage therapy and important developments have been achieved over the last years. But where do we stand today and what can we expect from phage therapy in the future? This is the question we set to answer in this review. Here, we scour the outcomes of human phage therapy clinical trials and case reports, and address the major barriers that stand in the way of using phages in clinical settings. We particularly address the potential of phage resistance to hinder phage therapy and discuss future avenues to explore the full capacity of phage therapy.Keywords
Funding Information
- FCT (PTDC/BBB-BSS/6471/2014)
This publication has 191 references indexed in Scilit:
- The Rise of Pathogens: Predation as a Factor Driving the Evolution of Human Pathogens in the EnvironmentMicrobial Ecology, 2013
- Co-evolution with lytic phage selects for the mucoid phenotype of Pseudomonas fluorescens SBW25The ISME Journal, 2011
- Bacteriophage Cocktail for the Prevention of Biofilm Formation by Pseudomonas aeruginosa on Catheters in an In Vitro Model SystemAntimicrobial Agents and Chemotherapy, 2010
- Amoxicillin and specific bacteriophage can be used together for eradication of biofilm of Klebsiella pneumoniae B5055World Journal of Microbiology and Biotechnology, 2009
- Multiplex Fast Real-Time PCR for Quantitative Detection and Identification of cos - and pac -Type Streptococcus thermophilus BacteriophagesApplied and Environmental Microbiology, 2008
- Microencapsulation of Bacteriophage Felix O1 into Chitosan-Alginate Microspheres for Oral DeliveryApplied and Environmental Microbiology, 2008
- Detection of Bacteriophage-Infected Cells of Lactococcus lactis by Using Flow CytometryApplied and Environmental Microbiology, 2007
- Dispersing biofilms with engineered enzymatic bacteriophageProceedings of the National Academy of Sciences of the United States of America, 2007
- Using Bacteriophages To Reduce Formation of Catheter-Associated Biofilms byStaphylococcus epidermidisAntimicrobial Agents and Chemotherapy, 2006
- Sociomicrobiology: the connections between quorum sensing and biofilmsTrends in Microbiology, 2005