Using the Golden Triangle to optimize clearance and oral absorption
- 15 August 2009
- journal article
- research article
- Published by Elsevier BV in Bioorganic & Medicinal Chemistry Letters
- Vol. 19 (19), 5560-5564
- https://doi.org/10.1016/j.bmcl.2009.08.045
Abstract
No abstract availableKeywords
This publication has 21 references indexed in Scilit:
- Defining optimum lipophilicity and molecular weight ranges for drug candidates—Molecular weight dependent lower logD limits based on permeabilityBioorganic & Medicinal Chemistry Letters, 2009
- Physiochemical drug properties associated with in vivo toxicological outcomesBioorganic & Medicinal Chemistry Letters, 2008
- Ligand Binding Efficiency: Trends, Physical Basis, and ImplicationsJournal of Medicinal Chemistry, 2008
- Structure−Brain Exposure RelationshipsJournal of Medicinal Chemistry, 2006
- Role of Caco-2 Cell Monolayers in Prediction of Intestinal Drug AbsorptionBiotechnology Progress, 2006
- A Comparison of Physiochemical Property Profiles of Development and Marketed Oral DrugsJournal of Medicinal Chemistry, 2003
- Molecular Properties That Influence the Oral Bioavailability of Drug CandidatesJournal of Medicinal Chemistry, 2002
- ElogDoct: A Tool for Lipophilicity Determination in Drug Discovery. 2. Basic and Neutral CompoundsJournal of Medicinal Chemistry, 2001
- Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settingsAdvanced Drug Delivery Reviews, 1997
- In vitro approaches can predict human drug metabolismTrends in Pharmacological Sciences, 1993