An Evaluation of Croscarmellose as a Tablet Disintegrant in Direct Compression Systems
- 1 January 1982
- journal article
- research article
- Published by Informa UK Limited in Drug Development and Industrial Pharmacy
- Vol. 8 (3), 397-410
- https://doi.org/10.3109/03639048209022108
Abstract
The disintegrant actions of croscarmellose type A (Ac-Di-Sol, FMC Corp.) and croscarmellose type B (CLD-2, Buckeye Cellulose Corp.) have been compared to that of corn starch in direct compression tablets in which microcrystalline cellulose (Avicel PH101, FMC Corp.) was the matrix. Two types of formulations were examined using either pyridoxine or hydrochlorothiazide as drug. The data clearly shows that both forns of croscarmellose are markedly superior to corn starch and are active at quite low concentrations. The CLD-2 may promote more rapid dissolution in some systems than Ac-Di-Sol.Keywords
This publication has 4 references indexed in Scilit:
- Evaluations of the Mechanism of Disintegrant ActionDrug Development and Industrial Pharmacy, 1982
- Some Effects of Relatively Low Levels of Eight Tablet Disintegrants on a Direct Compression SystemDrug Development and Industrial Pharmacy, 1981
- Studies of the Utility of Cross Linked Polyvinlpolypyrrolidine as a Tablet DisintegrantDrug Development and Industrial Pharmacy, 1980
- Further Studies of the Potential of Recording Powder Flow MetersDrug Development and Industrial Pharmacy, 1980