Protective Effects of Simvastatin, a Lipid Lowering Agent, against Oxidative Damage in Experimental Diabetic Rats
Open Access
- 6 December 2011
- journal article
- research article
- Published by Hindawi Limited in Journal of Lipids
- Vol. 2011, 1-13
- https://doi.org/10.1155/2011/167958
Abstract
The present study was undertaken to evaluate the possible protective effects of simvastatin (SMV) against oxidative stress in streptozotocin- (STZ)-induced diabetic rats. Diabetes was induced experimentally in rats by i.p. injection of STZ in a dose of 60 mg/kg bwt. After 5 weeks of STZ injection, there were apparent reductions in the animal body weight and significant increase in blood glucose, HbA1c, urea, creatinine, AST, ALT, and lipid profiles with a concomitant decrease in total hemoglobin, plasma glutathione and vitamin C as compared to the control group. The treatment with SMV at a dose (10 mg/kg, orally) normalized all the above-mentioned biochemical parameters in STZ-induced diabetic rats.In vitrostudies confirmed the free radical scavenging and antioxidant activity of SMV. Therefore, the present results revealed that SMV has a protective effect against STZ-induced oxidative damage by scavenging the free radicals generation and restoring the enzymatic and nonenzymatic antioxidant systems.Keywords
This publication has 65 references indexed in Scilit:
- Ascorbic acid prevents oxidant‐induced increases in endothelial permeabilityBioFactors, 2010
- Islets and their antioxidant defenseIslets, 2010
- The roles of NADPH‐oxidase and nNOS for the increased oxidative stress and the oxygen consumption in the diabetic kidneyDiabetes/Metabolism Research and Reviews, 2010
- Efeito da sinvastatina na sepse abdominal de ratos diabéticosRevista do Colégio Brasileiro de Cirurgiões, 2010
- Oxidative Stress, Nitric Oxide, and DiabetesThe Review of Diabetic Studies, 2010
- Statin Pleiotropy Against Renal InjuryJournal of the CardioMetabolic Syndrome, 2009
- Primed polymorphonuclear leukocytes constitute a possible link between inflammation and oxidative stress in hyperlipidemic patientsAtherosclerosis, 2008
- PLEIOTROPIC EFFECTS OF STATINSAnnual Review of Pharmacology and Toxicology, 2005
- Diabetes, oxidative stress, and antioxidants: A reviewJournal of Biochemical and Molecular Toxicology, 2003
- Glutathione peroxidase activity in selenium-deficient rat liverBiochemical and Biophysical Research Communications, 1976