Blocking interleukin-1β in acute and chronic autoinflammatory diseases
Open Access
- 10 November 2010
- journal article
- review article
- Published by Wiley in Journal of Internal Medicine
- Vol. 269 (1), 16-28
- https://doi.org/10.1111/j.1365-2796.2010.02313.x
Abstract
Dinarello CA (Department of Medicine, University of Colorado, Aurora, CO, USA). Blocking interleukin‐1β in acute and chronic autoinflammatory diseases. (Key Symposium) J Intern Med 2011; 269: 16–28. An expanding spectrum of acute and chronic inflammatory diseases is considered ‘autoinflammatory’ diseases. This review considers autoinflammatory diseases as being distinct from ‘autoimmune’ diseases. Autoimmune diseases are associated with dysfunctional T cells and treated with ‘biologicals’, including antitumour necrosis factorα, CTLA‐Ig, anti‐IL‐12/23, anti‐CD20, anti‐IL‐17 and anti‐IL‐6 receptor. In contrast, autoinflammatory diseases are uniquely attributed to a dysfunctional monocyte caspase 1 activity and secretion of IL‐1β; indeed, blocking IL‐1β results in a rapid and sustained reduction in the severity of most autoinflammatory diseases. Flares of gout, type 2 diabetes, heart failure and smouldering multiple myeloma are examples of seemingly unrelated diseases, which are uniquely responsive to IL 1β neutralization.Keywords
This publication has 96 references indexed in Scilit:
- The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin SensitivityCell Metabolism, 2010
- Engagement of fatty acids with toll‐like receptor 2 drives interleukin‐1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal–induced gouty arthritisArthritis & Rheumatism, 2010
- Constitutively Active Inflammasome in Human Melanoma Cells Mediating Autoinflammation via Caspase-1 Processing and Secretion of Interleukin-1βOnline Journal of Public Health Informatics, 2010
- Differential release of chromatin-bound IL-1α discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammationProceedings of the National Academy of Sciences of the United States of America, 2010
- Inflammatory arthritis in caspase 1 gene–deficient mice: Contribution of proteinase 3 to caspase 1–independent production of bioactive interleukin‐1βArthritis & Rheumatism, 2009
- The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot studyAnnals Of The Rheumatic Diseases, 2009
- In vivo regulation of interleukin 1β in patients with cryopyrin-associated periodic syndromesThe Journal of Experimental Medicine, 2009
- Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory DiseaseAnnual Review of Immunology, 2009
- Clinical Course and Prognosis of Smoldering (Asymptomatic) Multiple MyelomaThe New England Journal of Medicine, 2007
- Effects of Etanercept in Patients With the Metabolic SyndromeArchives of Internal Medicine, 2006