The Role of Anti-Cytokine Therapy in the Failing Heart
- 1 January 2001
- journal article
- review article
- Published by Springer Science and Business Media LLC in Heart Failure Reviews
- Vol. 6 (2), 143-151
- https://doi.org/10.1023/a:1011462011567
Abstract
The understanding of the role of ‘neurohormones’ in the progression of heart failure has led to the utilization of agents that antagonize the activation of neurohormonal systems as effective therapy in patients with heart failure. As more evidence emerges linking proinflammatory cytokines to disease progression in heart failure, there is an increasing interest in developing anti-cytokine strategies that might be used as adjunctive therapy in patients with heart failure. Accordingly, the focus of the present review is to summarize the experimental and clinical studies that have attempted to modulate the effects of cytokines in heart failure. Strategies have been employed to either suppress cytokine production or to prevent their toxic effects by interfering with the binding of cytokines to their cognate receptors.Keywords
This publication has 38 references indexed in Scilit:
- Randomised investigation of effects of pentoxifylline on left-ventricular performance in idiopathic dilated cardiomyopathyThe Lancet, 1998
- Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death.JCI Insight, 1996
- Interleukin-6 correlates with hemodynamic impairment during dobutamine administration in chronic heart failureInternational Journal of Cardiology, 1996
- Circulating Levels of Cytokines and Their Endogenous Modulators in Patients With Mild to Severe Congestive Heart Failure Due to Coronary Artery Disease or HypertensionJournal of the American College of Cardiology, 1996
- Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processingNature, 1994
- Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation.The Journal of Experimental Medicine, 1993
- Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes.The Journal of Experimental Medicine, 1991
- A Prospective, Randomized, Controlled Trial of Prednisone for Dilated CardiomyopathyNew England Journal of Medicine, 1989
- Isolation and characterization of a tumor necrosis factor binding protein from urineEuropean Journal of Haematology, 1989
- Drug-induced conditioning in congestive heart failure.Circulation, 1982