Squalene Emulsions for Parenteral Vaccine and Drug Delivery
Open Access
- 1 September 2009
- Vol. 14 (9), 3286-3312
- https://doi.org/10.3390/molecules14093286
Abstract
Squalene is a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery. In this review, the chemical structure and sources of squalene are presented. Moreover, the physicochemical and biological properties of squalene-containing emulsions are evaluated in the context of parenteral formulations. Historical and current parenteral emulsion products containing squalene or squalane are discussed. The safety of squalene-based products is also addressed. Finally, analytica techniques for characterization of squalene emulsions are examined.This publication has 131 references indexed in Scilit:
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