Priming for and induction of anti-poliovirus neutralizing antibodies by synthetic peptides
- 1 August 1983
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 304 (5928), 699-703
- https://doi.org/10.1038/304699a0
Abstract
Five peptides containing amino acid sequences from the type 1 poliovirus structural protein VP1 have been synthesized. Each of the peptides was found capable of priming the immune system of rabbits for a long-lasting, virus-neutralizing IgG antibody response following a single inoculation of intact virus. One peptide directly induced the production of neutralizing antibody.Keywords
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