Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardisation to be used in clinical trials
- 24 November 2010
- journal article
- recommendations
- Published by BMJ in Annals Of The Rheumatic Diseases
- Vol. 70 (3), 423-427
- https://doi.org/10.1136/ard.2010.139550
Abstract
Inflammation of synovium is one of the hallmarks of rheumatoid arthritis (RA). Analysis of synovial tissue has increased our understanding of RA pathogenesis, aided in identifying potential therapeutic targets and has been used in the response and mechanistic evaluation of antirheumatic treatments. In addition, studies are ongoing, aimed at the identification of diagnostic and prognostic biomarkers in the synovium. This paper outlines the currently used procedures for sampling and processing of synovial tissue, and presents a standardised recommendation to support multicentre translational research.This publication has 47 references indexed in Scilit:
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