Dietary Potassium Intake and Risk of Stroke in US Men and Women
- 1 July 2001
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 32 (7), 1473-1480
- https://doi.org/10.1161/01.str.32.7.1473
Abstract
Background and Purpose —The few prospective studies that have explored the association between dietary intake of potassium and risk of stroke have reported inconsistent findings. This study examines the relationship between dietary potassium intake and the risk of stroke in a representative sample of the US general population. Methods —Study participants included 9805 US men and women who participated in the first National Health and Nutrition Examination Survey (NHANES I) Epidemiologic Follow-Up Study. Dietary potassium and total energy intake were estimated at baseline by using a 24-hour dietary recall. Incidence data for stroke and coronary heart disease were obtained from medical records and death certificates. Results —Over an average of 19 years of follow up, 927 stroke events and 1847 coronary heart disease events were documented. Overall, stroke hazard was significantly different among quartiles of potassium intake (likelihood ratio P =0.03); however, a test of linear trend across quartiles did not reach a customary level of statistical significance ( P =0.14). Participants consuming a low potassium diet at baseline (P Conclusions —These findings suggest that low dietary potassium intake is associated with an increased risk of stroke. However, the possibility that the association is due to residual confounding cannot be entirely ruled out in this observational study.This publication has 21 references indexed in Scilit:
- Potassium, Blood Pressure, and Cardiovascular DiseaseCardiology in Review, 1997
- The effect of potassium supplementation in persons with a high-normal blood pressure: Results from phase I of the Trials of Hypertension Prevention (TOHP)Annals of Epidemiology, 1995
- Differences in morbidity measures and risk factor identification using multiple data sources: The case of coronary heart diseaseStatistics in Medicine, 1995
- Potassium inhibits free radical formation.Hypertension, 1994
- Increased Blood Pressure during Potassium Depletion in Normotensive MenThe New England Journal of Medicine, 1989
- Dietary Potassium and StrokeThe New England Journal of Medicine, 1988
- Dietary Potassium and Stroke-Associated MortalityThe New England Journal of Medicine, 1987
- Potassium reduces cerebral hemorrhage and death rate in hypertensive rats, even when blood pressure is not lowered.Hypertension, 1985
- Asymptotically Efficient Rank Invariant Test ProceduresJournal of the Royal Statistical Society. Series A (General), 1972
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958