New treatments for influenza
Open Access
- 13 September 2012
- journal article
- review article
- Published by Springer Science and Business Media LLC in BMC Medicine
- Vol. 10 (1), 104
- https://doi.org/10.1186/1741-7015-10-104
Abstract
Influenza has a long history of causing morbidity and mortality in the human population through routine seasonal spread and global pandemics. The high mutation rate of the RNA genome of the influenza virus, combined with assortment of its multiple genomic segments, promote antigenic diversity and new subtypes, allowing the virus to evade vaccines and become resistant to antiviral drugs. There is thus a continuing need for new anti-influenza therapy using novel targets and creative strategies. In this review, we summarize prospective future therapeutic regimens based on recent molecular and genomic discoveries.Keywords
This publication has 126 references indexed in Scilit:
- Fitness of neuraminidase inhibitor-resistant influenza A virusesCurrent Opinion in Virology, 2011
- Chemical inhibition of RNA viruses reveals REDD1 as a host defense factorNature Chemical Biology, 2011
- The host interactome of influenza virus presents new potential targets for antiviral drugsReviews in Medical Virology, 2011
- Genome-wide RNAi screen identifies human host factors crucial for influenza virus replicationNature, 2010
- A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 InfectionCell, 2009
- The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue VirusCell, 2009
- Human host factors required for influenza virus replicationNature, 2009
- Design and Pharmacological Characterization of Inhibitors of Amantadine-Resistant Mutants of the M2 Ion Channel of Influenza A VirusBiochemistry, 2009
- Emerging antiviral targets for influenza A virusTrends in Pharmacological Sciences, 2009
- Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-ICell Host & Microbe, 2009