The Role of Src Kinase in Macrophage-Mediated Inflammatory Responses
Open Access
- 11 November 2012
- journal article
- review article
- Published by Hindawi Limited in Mediators of Inflammation
- Vol. 2012, 1-18
- https://doi.org/10.1155/2012/512926
Abstract
Src kinase (Src) is a tyrosine protein kinase that regulates cellular metabolism, survival, and proliferation. Many studies have shown that Src plays multiple roles in macrophage-mediated innate immunity, such as phagocytosis, the production of inflammatory cytokines/mediators, and the induction of cellular migration, which strongly implies that Src plays a pivotal role in the functional activation of macrophages. Macrophages are involved in a variety of immune responses and in inflammatory diseases including rheumatoid arthritis, atherosclerosis, diabetes, obesity, cancer, and osteoporosis. Previous studies have suggested roles for Src in macrophage-mediated inflammatory responses; however, recently, new functions for Src have been reported, implying that Src functions in macrophage-mediated inflammatory responses that have not been described. In this paper, we discuss recent studies regarding a number of these newly defined functions of Src in macrophage-mediated inflammatory responses. Moreover, we discuss the feasibility of Src as a target for the development of new pharmaceutical drugs to treat macrophage-mediated inflammatory diseases. We provide insights into recent reports regarding new functions for Src that are related to macrophage-related inflammatory responses and the development of novel Src inhibitors with strong immunosuppressive and anti-inflammatory properties, which could be applied to various macrophage-mediated inflammatory diseases.Keywords
Funding Information
- National Research Foundation of Korea (0016397)
This publication has 138 references indexed in Scilit:
- Eps8 Protein Facilitates Phagocytosis by Increasing TLR4-MyD88 Protein Interaction in Lipopolysaccharide-stimulated MacrophagesOnline Journal of Public Health Informatics, 2012
- Lyn is a redox sensor that mediates leukocyte wound attraction in vivoNature, 2011
- Cysteine/cystine redox signaling in cardiovascular diseaseFree Radical Biology & Medicine, 2011
- The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesisAngiogenesis, 2010
- Differential Gene Expression Downstream of Toll-like Receptors (TLRs): ROLE OF c-Src AND ACTIVATING TRANSCRIPTION FACTOR 3 (ATF3)Online Journal of Public Health Informatics, 2010
- Saurolactam inhibits osteoclast differentiation and stimulates apoptosis of mature osteoclastsJournal of Cellular Physiology, 2009
- Direct and specific inactivation of protein tyrosine kinases in the Src and FGFR families by reversible cysteine oxidationProceedings of the National Academy of Sciences of the United States of America, 2009
- The Involvement of the Tyrosine Kinase c-Src in the Regulation of Reactive Oxygen Species Generation Mediated by NADPH Oxidase-1Molecular Biology of the Cell, 2008
- Mitogenic signaling pathways induced by G protein‐coupled receptorsJournal of Cellular Physiology, 2007
- Three-dimensional structure of the tyrosine kinase c-SrcNature, 1997