Chromatin in pluripotent embryonic stem cells and differentiation
- 17 May 2006
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Molecular Cell Biology
- Vol. 7 (7), 540-546
- https://doi.org/10.1038/nrm1938
Abstract
Embryonic stem (ES) cells are unique in that they are pluripotent and have the ability to self-renew. The molecular mechanisms that underlie these two fundamental properties are largely unknown. We discuss how unique properties of chromatin in ES cells contribute to the maintenance of pluripotency and the determination of differentiation properties.Keywords
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