Reliability of two‐dimensional and three‐dimensional pseudo‐continuous arterial spin labeling perfusion MRI in elderly populations: Comparison with 15o‐water positron emission tomography
Open Access
- 13 September 2013
- journal article
- research article
- Published by Wiley in Journal of Magnetic Resonance Imaging
- Vol. 39 (4), 931-939
- https://doi.org/10.1002/jmri.24246
Abstract
Purpose To investigate the reliability and accuracy of two pseudo‐continuous arterial spin labeling (pCASL) sequences, using two‐dimensional (2D) gradient‐echo echo planar imaging (EPI) and 3D gradient and spin echo (GRASE) as the readout, respectively. Materials and Methods Each sequence was performed twice 4 weeks apart on six normal control subjects, six elderly subjects with mild cognitive impairment (MCI), and one participant with Alzheimer's disease (AD). Eight of these subjects also underwent H215O positron emission tomography (PET) scans on the same day or proximal to their second MRI scan. The longitudinal repeatability of EPI and GRASE pCASL were evaluated with the intraclass correlation coefficient (ICC) and within‐subject coefficient of variation (wsCV). Results The ICCs of global perfusion measurements were 0.697 and 0.413 for GRASE and EPI based pCASL respectively. GRASE pCASL also demonstrated a higher longitudinal repeatability for regional perfusion measurements across 24 regions‐of‐interests (ICC = 0.707; wsCV = 10.9%) compared with EPI pCASL (ICC = 0.362; wsCV = 15.3%). When compared with PET, EPI pCASL showed a higher degree of spatial correlation with PET than GRASE pCASL, although the difference was not statistically significant. Conclusion The 3D GRASE pCASL offers better repeatability than 2D EPI pCASL, thereby may provide a reliable imaging marker for the evaluation of disease progression and treatment effects in MCI and early AD subjects. J. Magn. Reson. Imaging 2014;39:931–939.This publication has 30 references indexed in Scilit:
- The Value of Arterial Spin-Labeled Perfusion Imaging in Acute Ischemic StrokeStroke, 2012
- Regional reproducibility of pulsed arterial spin labeling perfusion imaging at 3TNeuroImage, 2011
- Reliability and precision of pseudo‐continuous arterial spin labeling perfusion MRI on 3.0 T and comparison with 15O‐water PET in elderly subjects at risk for Alzheimer's diseaseNMR in Biomedicine, 2010
- The clinical use of structural MRI in Alzheimer diseaseNature Reviews Neurology, 2010
- MRI-derived measurements of human subcortical, ventricular and intracranial brain volumes: Reliability effects of scan sessions, acquisition sequences, data analyses, scanner upgrade, scanner vendors and field strengthsNeuroImage, 2009
- Test-retest variability of quantitative [11C]PIB studies in Alzheimer’s diseaseEuropean Journal of Nuclear Medicine and Molecular Imaging, 2009
- Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's diseaseBrain, 2009
- Mild Cognitive Impairment and Alzheimer Disease: Patterns of Altered Cerebral Blood Flow at MR ImagingRadiology, 2009
- Continuous flow‐driven inversion for arterial spin labeling using pulsed radio frequency and gradient fieldsMagnetic Resonance in Medicine, 2008
- Hippocampal hyperperfusion in Alzheimer's diseaseNeuroImage, 2008