The Histopathologic and Molecular Basis for the Diagnosis of Histiocytic Sarcoma and Histiocyte–Associated Lymphoma of Mice
Open Access
- 14 May 2010
- journal article
- research article
- Published by SAGE Publications in Veterinary Pathology
- Vol. 47 (3), 434-445
- https://doi.org/10.1177/0300985810363705
Abstract
Histiocytic sarcoma (HS) and histiocyte–associated lymphoma (HAL) of mice are difficult to distinguish histologically. Studies of multiple cases initially diagnosed as HS or HAL allowed us to define HS as round, fusiform, or mixed cell types that were F4/80+, Mac–2+, and PAX5–; that lacked markers for other sarcomas; and that had immune receptor genes in germline configuration. Two other subsets had clonal populations of lymphocytes. The first, HAL, featured malignant lymphocytes admixed with large populations of normal–appearing histiocytes. The second appeared to be composites of lymphoma and HS. Several cases suggestive of B myeloid–lineage plasticity were also observed.Keywords
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