Currently Used Cholinesterase Reactivators Against Nerve Agent Intoxication: Comparison of Their Effectivity in Vitro
- 1 January 2007
- journal article
- research article
- Published by Taylor & Francis Ltd in Drug and Chemical Toxicology
- Vol. 30 (1), 31-40
- https://doi.org/10.1080/01480540601017637
Abstract
In vitro comparison of reactivation efficacy of five currently used oximes—pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6 (at two concentrations: 10−5 and 10−3 M)—against acetylcholinesterase (AChE; E.C. 3.1.1.7) inhibited by six different nerve agents (VX, Russian VX, sarin, cyclosarin, tabun, soman) and organophosphorus insecticide chlorpyrifos was the aim of this study. As a source of AChE in the experiments, rat brain homogenate was used. According to the results obtained, no AChE reactivator was able to reach sufficient potency for AChE inhibited by all nerve agents used. Moreover, oxime HI-6 (the most effective one) was not able to reactivate tabun- and soman-inhibited AChE. Due to this fact, it could be designated as a partially broad-spectrum reactivator.Keywords
This publication has 12 references indexed in Scilit:
- Evaluation of oxime efficacy in nerve agent poisoning: Development of a kinetic-based dynamic modelToxicology and Applied Pharmacology, 2005
- Effective bisquaternary reactivators of tabun-inhibited AChEJournal of Applied Toxicology, 2005
- Evaluation of Newly Synthesized Reactivators of the Brain Cholinesterase Inhibited by Sarin Nerve AgentToxicology Mechanisms and Methods, 2005
- Organophosphates⧸Nerve Agent Poisoning: Mechanism of Action, Diagnosis, Prophylaxis, And TreatmentAdvances in Clinical Chemistry, 2004
- A Comparison of the Ability of a New Bispyridinium Oxime—1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane Dibromide and Currently used Oximes to Reactivate Nerve Agent-inhibited Rat Brain Acetylcholinesterase byIn VitroMethodsJournal of Enzyme Inhibition and Medicinal Chemistry, 2003
- Nerve Agent Attacks on Children: Diagnosis and ManagementPEDIATRICS, 2003
- The Role of Oximes in the Management of Organophosphorus Pesticide PoisoningToxicological Reviews, 2003
- Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphatesArchives of Toxicology, 2002
- Review of Oximes in the Antidotal Treatment of Poisoning by Organophosphorus Nerve AgentsJournal of Toxicology: Clinical Toxicology, 2002
- Dealkylation as a mechanism for aging of cholinesterase after poisoning with pinacolyl methylphosphonofluoridateBiochemical Pharmacology, 1965