The Value of Immunohistochemical Studies Using Antibody to S100 Protein in Dermatopathology
- 1 January 1984
- journal article
- Published by Wiley in International Journal of Dermatology
- Vol. 23 (1), 38-44
- https://doi.org/10.1111/j.1365-4362.1984.tb05661.x
Abstract
The distribution of S100 protein in normal skin and various tumors involving skin was assessed using rabbit antibody to S100 protein in an immunoperoxidase reaction. In normal skin, S100 protein was detected in the epidermis (melanocytes and Langerhans' cells), dermis (Schwann cells, Pacinian and Meissner's corpuscles, and interdigitating reticulum cells), cells of the sweat gland apparatus, and in chondrocytes. In tumors involving skin, S100 protein was present in nevi, malignant melanomas, histiocytosis X, mixed sweat gland tumors, neural tumors, chondromas, and chondrosarcomas. Detection of S100 protein by immunostaining was useful in understanding the histogenesis of various skin tumors and in assessing the diagnosis and prognosis of a variety of skin lesions encountered in surgical pathology.Keywords
This publication has 26 references indexed in Scilit:
- S-100 protein in human chondrocytesNature, 1982
- Immunochemical and immunocytochemical localization of S-100 antigen in normal human skinNature, 1981
- S100 PROTEIN: A MARKER FOR HUMAN MALIGNANT MELANOMAS?The Lancet, 1981
- Immunohistochemical localisation of S–100 protein in brainNature, 1975
- Synthesis of S‐100 Protein in Monolayer Cultures of Rat‐Glial CellsJBIC Journal of Biological Inorganic Chemistry, 1975
- S-100 protein in synapses of the central nervous systemNature, 1974
- Effect of calcium ion on S-100, a protein of the nervous systemBiochemistry, 1969
- Biochemically differentiated clonal human glial cells in tissue cultureJournal of Neurobiology, 1969
- Differentiated Rat Glial Cell Strain in Tissue CultureScience, 1968
- A soluble protein characteristic of the nervous systemBiochemical and Biophysical Research Communications, 1965