Biosynthesis of isoprenoids in higher plant chloroplasts proceeds via a mevalonate‐independent pathway
- 6 January 1997
- journal article
- Published by Wiley in FEBS Letters
- Vol. 400 (3), 271-274
- https://doi.org/10.1016/s0014-5793(96)01404-4
Abstract
Isopentenyl diphosphate (IPP) is the biological C5 precursor of isoprenoids. By labeling experiments using [1-(13)C]glucose, higher plants were shown to possess two distinct biosynthetic routes for IPP biosynthesis: while the cytoplasmic sterols were formed via the acetate/mevalonate pathway, the chloroplast-bound isoprenoids (beta-carotene, lutein, prenyl chains of chlorophylls and plastoquinone-9) were synthesized via a novel IPP biosynthesis pathway (glyceraldehyde phosphate/pyruvate pathway) which was first found in eubacteria and a green alga. The dichotomy in isoprenoid biosynthesis in higher plants allows a reasonable interpretation of previous odd and inconclusive results concerning the biosynthesis of chloroplast isoprenoids, which so far had mainly been interpreted in the frame of models using compartmentation of the mevalonate pathway.Keywords
This publication has 22 references indexed in Scilit:
- Glyceraldehyde 3-Phosphate and Pyruvate as Precursors of Isoprenic Units in an Alternative Non-mevalonate Pathway for Terpenoid BiosynthesisJournal of the American Chemical Society, 1996
- The Role of Plastids in Isoprenoid BiosynthesisAnnual Review of Plant Physiology and Plant Molecular Biology, 1989
- Evidence for a mevalonate shunt in a tracheophyteProceedings of the Royal Society of London. B. Biological Sciences, 1985
- The role of leucine in isoprenoid metabolism. Incorporation of [3-13C]leucine and of [2-3H,4-14C]-β,β-dimethylacrylic acid into phytosterols by tissue cultures of Andrographis paniculataJournal of the Chemical Society, Chemical Communications, 1985
- Inhibition by mevinolin of plant growth, sterol formation and pigment accumulationPhysiologia Plantarum, 1983
- The role of leucine in terpenoid metabolism. Incorporation of [2-13C]- and [3-13C]-leucines into sesquiterpenoids by tissue cultures of Andrographis paniculataJournal of the Chemical Society, Chemical Communications, 1983
- Embryos of Maize (Zea mays)Published by Springer Science and Business Media LLC ,1982
- A Revised Medium for Rapid Growth and Bio Assays with Tobacco Tissue CulturesPhysiologia Plantarum, 1962
- Biosynthesis of Isoprenoid CompoundsAnnual Review of Biochemistry, 1961
- Comet NotesPublications of the Astronomical Society of the Pacific, 1958