Case Definition and Phenotype Standardization in Drug-Induced Liver Injury
Top Cited Papers
- 4 May 2011
- journal article
- review article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 89 (6), 806-815
- https://doi.org/10.1038/clpt.2011.58
Abstract
Drug-induced liver injury (DILI) is the most frequent reason cited for the withdrawal of approved drugs from the market and accounts for up to 15% of the cases of acute liver failure. Investigators around the globe have begun to identify and study patients with DILI; several large registries and tissue banks are being established. In order to gain the maximum scientific benefit from these efforts, the definitions and terminology related to the clinical phenotypes of DILI must be harmonized. For this purpose, an international DILI Expert Working Group of clinicians and scientists reviewed current DILI terminology and diagnostic criteria so as to develop more uniform criteria that would define and characterize the spectrum of clinical syndromes that constitute DILI. Consensus was established with respect to the threshold criteria for definition of a case as being DILI, the pattern of liver injury, causality assessment, severity, and chronicity. Consensus was also reached on approaches to characterizing DILI in the setting of chronic liver diseases, including autoimmune hepatitis (AIH).Keywords
This publication has 72 references indexed in Scilit:
- The Emerging Role of Electronic Medical Records in PharmacogenomicsClinical Pharmacology & Therapeutics, 2011
- Drugs Associated with Hepatotoxicity and their Reporting Frequency of Liver Adverse Events in VigiBase™Drug Safety, 2010
- Standardization of nomenclature and causality assessment in drug-induced liver injury: Summary of a clinical research workshopHepatology, 2010
- Causality assessment in drug-induced liver injury using a structured expert opinion process: Comparison to the Roussel-Uclaf causality assessment methodHepatology, 2010
- MedEx: a medication information extraction system for clinical narrativesJournal of the American Medical Informatics Association, 2010
- Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United StatesGastroenterology, 2008
- Telithromycin-associated hepatotoxicity: Clinical spectrum and causality assessment of 42 casesHepatology, 2008
- Using controlled clinical trials to learn more about acute drug-induced liver injuryHepatology, 2008
- Performance parameters of the diagnostic scoring systems for autoimmune hepatitisHepatology, 2008
- AASLD position paper: The management of acute liver failureHepatology, 2005