Spinal plasticity following intermittent hypoxia: implications for spinal injury
- 10 June 2010
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1198 (1), 252-259
- https://doi.org/10.1111/j.1749-6632.2010.05499.x
Abstract
Plasticity is a fundamental property of the neural system controlling breathing. One frequently studied model of respiratory plasticity is long‐term facilitation of phrenic motor output (pLTF) following acute intermittent hypoxia (AIH). pLTF arises from spinal plasticity, increasing respiratory motor output through a mechanism that requires new synthesis of brain‐derived neurotrophic factor, activation of its high‐affinity receptor, tropomyosin‐related kinase B, and extracellular‐related kinase mitogen‐activated protein kinase signaling in or near phrenic motor neurons. Because intermittent hypoxia induces spinal plasticity, we are exploring the potential to harness repetitive AIH as a means of inducing functional recovery in conditions causing respiratory insufficiency, such as cervical spinal injury. Because repetitive AIH induces phenotypic plasticity in respiratory motor neurons, it may restore respiratory motor function in patients with incomplete spinal injury.Keywords
This publication has 56 references indexed in Scilit:
- Spinal adenosine A2A receptor inhibition enhances phrenic long term facilitation following acute intermittent hypoxiaThe Journal of Physiology, 2010
- Multiple Pathways to Long-Lasting Phrenic Motor FacilitationAdvances in experimental medicine and biology, 2009
- Spinal circuitry and respiratory recovery following spinal cord injuryRespiratory Physiology & Neurobiology, 2009
- Intermittent hypoxia induces functional recovery following cervical spinal injuryRespiratory Physiology & Neurobiology, 2009
- Episodic spinal serotonin receptor activation elicits long‐lasting phrenic motor facilitation by an NADPH oxidase‐dependent mechanismThe Journal of Physiology, 2009
- Daily intermittent hypoxia augments spinal BDNF levels, ERK phosphorylation and respiratory long-term facilitationExperimental Neurology, 2009
- NADPH oxidase activity is necessary for acute intermittent hypoxia-induced phrenic long-term facilitationThe Journal of Physiology, 2009
- Reactive oxygen species and respiratory plasticity following intermittent hypoxiaRespiratory Physiology & Neurobiology, 2008
- Determinants of frequency long-term facilitation following acute intermittent hypoxia in vagotomized ratsRespiratory Physiology & Neurobiology, 2008
- Respiratory long-term facilitation following intermittent hypoxia requires reactive oxygen species formationNeuroscience, 2008