Investigation into species variants in tachykinin NK1 receptors by use of the non‐peptide antagonist, CP‐96,345

Abstract

The affinity of the non-peptide antagonist CP-96,345 for tachykinin NK₁ receptors has been estimated in a range of species by use of both radioligand binding and functional assays. CP-96,345 was 30–120 fold less active at NK₁ receptors in rat and mouse than in the other species examined, including man. These results demonstrate the existence of species variations in NK₁ receptors.