On the toxicokinetics and the metabolism of deoxynivalenol (don) in the pig
- 1 April 2004
- journal article
- research article
- Published by Taylor & Francis Ltd in Archives of Animal Nutrition
- Vol. 58 (2), 169-180
- https://doi.org/10.1080/00039420410001667548
Abstract
Eleven castrated male pigs weighing 88.1 ± 3.9 kg on average were adapted to a diet containing DON (4.2 mg DON/kg) over a period of 7 days. Feed was given restrictively with 1.1 kg per meal (two meals per day). On the day of measurement, all pigs were slaughtered at different time intervals following the morning meal containing DON (1, 2, 3, 4, 5, 6, 8, 15, 18 and 24 h after feeding), with the exception of one pig which was slaughtered unfed. DON and de-epoxy-DON were analysed in serum and digesta from consecutive segments of the digestive tract (stomach, small intestine divided into three parts of a similar length, caecum, colon, rectum). DON was rapidly and nearly completely absorbed while passing through the stomach and the proximal small intestine. Maximum serum concentration appeared 4.1 h after the DON-containing meal and half of the systemically absorbed DON was eliminated after 5.8 h. De-epoxy-DON appeared in increasing proportions from the distal small intestine and reached approximately 80% of the sum of DON plus de-epoxy-DON in faeces collected from the rectum. It was concluded that de-epoxydation of DON, which primarily occurs in the hindgut, probably does not contribute much to a detoxification in the pig.Keywords
This publication has 9 references indexed in Scilit:
- Effects of graded levels ofFusariumtoxin contaminated maize in diets for female weaned pigletsArchives of Animal Nutrition, 2003
- Absorption, metabolism and excretion of 3-acetyl DON in pigs.Archives of Animal Nutrition, 2003
- Analysis of deoxynivalenol and de-epoxy-deoxynivalenol in animal tissues by liquid chromatography after clean-up with an immunoaffinity columnMycotoxin Research, 2003
- Transformation of Trichothecenes in Ileal Digesta and Faeces from PigsArchives of Animal Nutrition, 2002
- Metabolisierung von Deoxynivalenol beim Schwein: Bestimmung von DON und DOM-1 im Urin vom SchweinMycotoxin Research, 2002
- Determination of eight trichothecenes by gas chromatography–mass spectrometry after sample clean-up by a two-stage solid-phase extractionJournal of Chromatography A, 1998
- In vitro transformation of the Fusarium mycotoxins deoxynivalenol and zearalenone by the normal gut microflora of pigsNatural Toxins, 1994
- Pharmacokinetic fate of 14C-labeled deoxynivalenol in swine*1Fundamental and Applied Toxicology, 1988
- Transformation of deoxynivalenol (vomitoxin) by rumen microorganismsJournal of Agricultural and Food Chemistry, 1984