Melanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment
Top Cited Papers
Open Access
- 1 January 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Communications
- Vol. 3 (1), 884
- https://doi.org/10.1038/ncomms1893
Abstract
Malignant melanoma of the skin (CMM) is associated with ultraviolet radiation exposure, but the mechanisms and even the wavelengths responsible are unclear. Here we use a mammalian model to investigate melanoma formed in response to precise spectrally defined ultraviolet wavelengths and biologically relevant doses. We show that melanoma induction by ultraviolet A (320–400 nm) requires the presence of melanin pigment and is associated with oxidative DNA damage within melanocytes. In contrast, ultraviolet B radiation (280–320 nm) initiates melanoma in a pigment-independent manner associated with direct ultraviolet B DNA damage. Thus, we identified two ultraviolet wavelength-dependent pathways for the induction of CMM and describe an unexpected and significant role for melanin within the melanocyte in melanomagenesis.Keywords
This publication has 63 references indexed in Scilit:
- β-Catenin Signaling Controls Metastasis in Braf-Activated Pten-Deficient MelanomasCancer Cell, 2011
- Exome sequencing identifies GRIN2A as frequently mutated in melanomaNature Genetics, 2011
- Interferon-γ links ultraviolet radiation to melanomagenesis in miceNature, 2011
- Melanocytes are deficient in repair of oxidative DNA damage and UV-induced photoproductsProceedings of the National Academy of Sciences, 2010
- Ultraviolet A does not induce melanomas in a Xiphophorus hybrid fish modelProceedings of the National Academy of Sciences of the United States of America, 2010
- A comprehensive catalogue of somatic mutations from a human cancer genomeNature, 2009
- Increasing Burden of Melanoma in the United StatesJournal of Investigative Dermatology, 2009
- Melanoma EpidemiologyHematology/Oncology Clinics of North America, 2009
- Evidence of ultraviolet type mutations in xeroderma pigmentosum melanomasProceedings of the National Academy of Sciences of the United States of America, 2009
- Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiationProceedings of the National Academy of Sciences, 2006