mTOR, translation initiation and cancer
Top Cited Papers
- 16 October 2006
- journal article
- review article
- Published by Springer Science and Business Media LLC in Oncogene
- Vol. 25 (48), 6416-6422
- https://doi.org/10.1038/sj.onc.1209888
Abstract
Control of mRNA translation plays a fundamental role in many aspects of cell metabolism. It constitutes a critical step in the control of gene expression, and consequently cell growth, proliferation and differentiation. Translation is regulated in response to nutrient availability, hormones, mitogenic and growth factor stimulation and is coupled with cell cycle progression and cell growth. Signaling by the PI3K/Akt/mTOR pathway profoundly affects mRNA translation through phosphorylation of downstream targets such as 4E-BP and S6K. Inhibitors of this pathway and thus cap-dependent translation are emerging as promising therapeutic options for the treatment of cancer.This publication has 77 references indexed in Scilit:
- The TOR signalling network from yeast to manThe International Journal of Biochemistry & Cell Biology, 2006
- The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activityThe EMBO Journal, 2006
- eIF3: A ConnecTOR of S6K1 to the Translation Preinitiation ComplexMolecular Cell, 2005
- Exploiting the PI3K/AKT Pathway for Cancer Drug DiscoveryNature Reviews Drug Discovery, 2005
- Vascular Endothelial Growth Factor Transcriptional Activation Is Mediated by Hypoxia-inducible Factor 1α, HDM2, and p70S6K1 in Response to Phosphatidylinositol 3-Kinase/AKT SignalingPublished by Elsevier BV ,2004
- PTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomasHepatology, 2003
- Sustained Activation of the JNK Cascade and Rapamycin-Induced Apoptosis Are Suppressed by p53/p21Cip1Molecular Cell, 2003
- TOR signalling in bugs, brain and brawnNature Reviews Molecular Cell Biology, 2003
- Global and Specific Translational Control by Rapamycin in T Cells Uncovered by Microarrays and ProteomicsPublished by Elsevier BV ,2002
- 4E-binding Proteins, the Suppressors of Eukaryotic Initiation Factor 4E, Are Down-regulated in Cells with Acquired or Intrinsic Resistance to RapamycinPublished by Elsevier BV ,2002