Why is Parity Protective for Uterine Fibroids?
- 1 March 2003
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Epidemiology
- Vol. 14 (2), 247-250
- https://doi.org/10.1097/01.ede.0000054360.61254.27
Abstract
Uterine fibroids are benign tumors, the etiology of which is not understood. Symptoms can be debilitating, and the primary treatment is surgery, usually hysterectomy. Epidemiologic data show that pregnancy is associated with reduced risk of fibroids. We hypothesize that this association is attributable to a protective effect of postpartum involution of the uterus. After each pregnancy the uterus rapidly returns to prepregnancy size by dramatic remodeling of the tissue. We hypothesize that small fibroids are eliminated during this process. We present preliminary epidemiologic evidence that is consistent with this hypothesis. If the hypothesis is supported by more direct evidence, it may have broader implications, supporting the idea that tissue remodeling may be a general mechanism for limiting tumor development.Keywords
This publication has 33 references indexed in Scilit:
- Hysterectomy rates in the United States 1990–1997Obstetrics & Gynecology, 2002
- Smooth Muscle, Endometrial Stromal, and Mixed Müllerian Tumors of the UterusLaboratory Investigation, 2000
- Uterine Myomas in Adolescents: Case Reports and a Review of the LiteratureJournal of Pediatric and Adolescent Gynecology, 1996
- Clonal Determination of Uterine Leiomyomas by Analyzing Differential Inactivation of the X-Chromosome-Linked Phosphoglycerokinase GeneGynecologic and Obstetric Investigation, 1995
- The Maine Womenʼs Health StudyObstetrics & Gynecology, 1994
- The Frequency of Uterine LeiomyomasAmerican Journal of Clinical Pathology, 1990
- Leiomyomas in pregnancy: sonographic study.Radiology, 1987
- Risk factors for uterine fibroids: reduced risk associated with oral contraceptives.BMJ, 1986
- Myomas of the uterus in pregnancy: Ultrasonographic follow-upAmerican Journal of Obstetrics and Gynecology, 1980
- Unicellular histogenesis of uterine leiomyomas as determined by electrophoresis of glucose-6-phosphate dehydrogenaseAmerican Journal of Obstetrics and Gynecology, 1970