A population-based study of the incidence and prognosis of lacunar stroke
- 9 May 2006
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Neurology
- Vol. 66 (9), 1335-1338
- https://doi.org/10.1212/01.wnl.0000210457.89798.0e
Abstract
Objective: To evaluate incidence and prognosis of lacunar stroke in a prospective, population-based patient registry. Methods: The authors included first-ever strokes occurring between 1994 and 1998. They assessed incidence, risk factors, mortality, and recurrence in patients with lacunar stroke. Results: The authors identified 491 patients (15.3%) with lacunar stroke (252 men and 239 women) and 2,153 patients (67.3%) with nonlacunar stroke (998 men and 1,155 women). Crude annual incidence rate for a first-ever lacunar stroke was 33.0/100,000 (95% CI 30.2 to 36.0). At the univariate logistic regression analysis among patients with lacunar stroke there was a higher proportion of cigarette smoking and hypercholesterolemia and a lower proportion of chronic atrial fibrillation than in patients with nonlacunar stroke. For lacunar stroke, the 30-day case-fatality rate was 4.3% (95% CI 2.5 to 6.1) and the 1-year case-fatality rate was 13.0% (95% CI 10.0 to 16.0). During the first year of follow-up the average annual stroke recurrence rate was lower in patients with lacunar (2.83%; 95% CI 1.36 to 4.30) than in those with nonlacunar stroke (5.10%; 95% CI 4.17 to 6.03) while from the second year onward, rates were similar in both groups. Conclusion: In the short term, patients with nonlacunar stroke had more vascular events, but in the long term, the risk of death and of stroke recurrence was similar.Keywords
This publication has 15 references indexed in Scilit:
- Are Lacunar Strokes Really Different?Stroke, 2005
- High Stroke Incidence in the Prospective Community-Based L’Aquila Registry (1994–1998)Stroke, 1997
- Risk factors for lacunar infarction syndromesNeurology, 1995
- An Analysis of Ischemic Stroke in an Urban Southern California PopulationArchives of Internal Medicine, 1993
- Epidemiological characteristics of lacunar infarcts in a population.Stroke, 1991
- SEPIVAC: a community-based study of stroke incidence in Umbria, Italy.Journal of Neurology, Neurosurgery & Psychiatry, 1991
- Infarcts in the territory of the deep perforators from the carotid systemNeurology, 1989
- The natural history of lacunar infarction: the Oxfordshire Community Stroke Project.Stroke, 1987
- LacunesNeurology, 1965